This unit introduces the concepts necessary for an appreciation of medicinal chemistry, thereby providing a solid background for employment in the drug discovery industry. The syllabus begins with an overview of drugs and medicinal chemistry and then considers the pharmacodynamic and pharmacokinetic properties essential for useful drugs including a survey of biological (macromolecular) targets, the energetics of drug target interactions, molecular recognition, absorption, distribution, metabolism and excretion (ADME). The process of drug discovery and design is explored, beginning with factors affecting choice of disease/biological target, the discovery of lead compounds and then... -- Course Website
Instructor: Associate Professor Matthew Piggott
Prerequisites: CHEM2210 Structure Determination and Physical Chemistry and CHEM2221 Biological and Medicinal Chemistry